|Title (4 marks)|
|1.||Is the PICO stated? If yes,||P: NA|
|I: Helicobacter Pylori Eradication|
|O: Gastric Mucosal Atrophy and Gastric Cancer|
|Problem Statement/ Hypothesis (6 marks)|
|1.||What is/are the problem statement?||To clarify the status of atrophic gastritis at the time point that patients developed gastric cancer after Helicobacter pylori.
|2.||What is/are the hypothesis?||NA
|3.||What is/are the research Question(s)?||Are there any possibilities that after helicobacter pylori eradication has a link between gastric mucosal atrophy and gastric cancer?
|Variables ( 2 marks)|
|1.||Independent Variable/s||Gastric Mucosal Atrophy and Helicobacter Pylori Eradication|
|2.||Dependent Variable/s||Gastric Cancer|
|Research Methodology (7 marks)|
(Country, Hospital, school etc.)
|Endoscopy Center of Fujita Health University|
(E.g. probability random sampling)
(Age, Gender etc.)
|55 consecutive patients with 64 early gastric cancers diagnosed after successful Helicobacter pylori eradication
(e.g. Randomized control trial)
|7.||Tools/Instruments used for outcome measures
(Questionnaires, Weighing Scale, Blood test etc.)
|Urea breath test and histological assessments using endoscopic biopsy specimens obtain from non-pathological mucosa of the greater curvature of the gastric antrum and upper corpus.
|Discussion (6 marks)|
|1.||Strength of the study||Study showed that majority of gastric cancer after Helicobacter pylori eradication develop in the endoscopic atrophic mucosa or at atrophic border, which is characterized as high degrees of histological atrophy and intestinal metaplasia. The endoscopic surveillance of gastric cancer after H. pylori eradication should be performed, always pay careful attention to the atrophic area.
|2.||Limitations of the study||The study deserves more intensive study to establish the strategy for the early diagnosis, treatment and prevention of gastric cancer after H. pylori eradication.